Endocrine Abstracts

Background: The aim of this case report is to underline the possible etiological link between paroxysmal supraventricular tachycardia (PSVT) and hypothyroidism, although supraventricular arrhythmias are ordinary features of hyperthyroidism. We present the case of a patient with repetitive episodes of PSVT whose autoimmune hypothyroidism was diagnosed and thyroxin replacement therapy leaded to remission of arrhythmia.Methods: A 47 year old women with a lo...

Background: Glucocorticoid resistance syndrome is a rare, familial or sporadic disease, caused by genetic mutations of the glucocorticoid receptor or at any other level of the signaling pathway. It is characterized by general, partial, target-tissue insensitivity to glucocorticoids, leading to activation of the hypothalamo–hypophysis–adrenal axis resulting in compensatory increased levels of cortisol, but also increased concentrations of adrenal products with mineral...

Background: Metabolomics profiling of bio-fluids suggests altered signatures in patients with the polycystic ovary syndrome (PCOS).Subjects and methods: A high-performance liquid chromatography/time-of-flight mass spectrometry (HPLC/TOF-MS)-based metabolomics approach was developed to characterize the untargeted lipidomics signature associated with PCOS status in a discovery cohort of 30 plasma samples (15 PCOS, 15 controls, age-matched), followed in a s...

Introduction: Type 1 diabetes secondary osteoporosis is an underdiagnosed condition and there are few studies that addressed the topic of clinical risk factors in this context, although, for a better diagnosis and management, it is of great importance to find such predictors.Aim: To evaluate bone mineral density and parameters of bone metabolism in patients with type 1 diabetes in comparison with a group of healthy subjects and to determine possible risk...

One of the causes of secondary osteoporosis is type 1 DM (1DM), an autoimmune disease where insulin replacement is mandatory for controlling blood sugar levels. Among the mechanisms involved in osteoporosis in 1DM is increased bone resorption, mainly osteoclasts being responsible for this process. However, osteoblasts also seem to have an active contribution by secreting products with resorptive properties, one of these being cysteine protease Cathepsin K, as mentioned by a fe...